Synthetic, Structural and Antimicrobial Studies of Some Substituted 2,6-Diphenyl-1-aza-7-oxa-4-spiro[2,5]octanes

M. Jambulingam*, Asha Sathish, J. Vasanthakumar and K. Rakkiyappan†

Department of Chemistry, P.S.G. College of Arts and Science, Coimbatore-641 014, India

†Principal Scientist, Sugarcane Breeding Institute, Coimbatore-641 007, India



Different methyl substituted 2,6-diphenyl piperidones have been synthesized and subjected to the reaction with dimethyl sulphoxonium methyl ylide in the presence of potassium tertiary butoxide for the preparation of the corresponding spiro oxiranes. The structures of the products have been confirmed by various physical techniques.


Synthesis, Antimicrobial studies, Spiro oxiranes, Substituted 2,6-diphenyl-1-aza-7-oxa-4-spiro[2,5]octanes.

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  • Asian J. Chem. /
  •  2004 /
  •  16(3) /
  •  pp 1261-1268