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Theoretical Study of the Inhibition of ?-Secretase
I. ABDELLI, S. SARI, C. ZIANI-CH+RIF and S. GHALEM*

Laboratory of Organics Chemistry, Analyses and Natural Substances (COSNA)
Department of Chemistry, Faculty of Sciences Aboubakr Belkaid University
Tlemcen, Algeria
E-mail: s_ghalem2002@yahoo.fr; i_abdelli@yahoo.fr

Abstract

The brain of the human being suffering of the Alzheimer disease undergoes modifications caused by enzymes e.g., β-secretase and γ-secretase. These enzymes produce fragments of amyloid β. The inhibition of the cleavage of this amyloïd β by enzymes β and γ-secretase prevents the amyloïd forming deposits plates and can improve the efficiency of the system of the elimination. Our research objective is to study the inhibition of the β-secretase by the methods of molecular modelling.

Keywords

Alzheimer disease, ?-Secretase inhibitors, Molecular modelling.
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  • Asian J. Chem. /
  •  2007 /
  •  19(7) /
  •  pp 5407-5416