Removal of Cholesterol by b-Cyclodextrin

Huiming Jiang1,2,*, Shufen Zhang1 and Qi Shi2

1State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116012, P.R. China

2Department of Chemical Engineering, College of Life Science, Dalian Nationalities University, Dalian 116600, P.R. China

*Corresponding author: E-mail: yellowriveryy@yahoo.com.cn

Abstract

This paper reviews cholesterol removal methods by b-cyclodextrin or its derivatives. Cholesterol was complexed by b-cyclodextrin or its derivatives in two major ways i.e., molecular imprinting and direct inclusion. It revealed that b-cyclodextrin dimers linked via different bridges exhibited much higher binding capability than b-cyclodextrin itself, of which, a b-cyclodextrin dimer linked by a thioether bridge exhibits the highest binding constant with cholesterol, which reaches up to (3.30 ± 0.80) × 106.

Keywords

Cholesterol, Removal, b-Cyclodextrin, Molecular imprinting.

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  • Asian J. Chem. /
  •  2011 /
  •  23(9) /
  •  pp 3783-3786