Comparative Study of Various Green Chemistry Approaches for the Efficient Synthesis of 1,4-Dihydropyridines

Prabhjot Kaur, Heena Sharma, Rekha Rana, D.N. Prasad and Rajesh K. Singh*

Pharmaceutical Chemistry Division, Shivalik College of Pharmacy, Nangal, Distt-Rupnagar, 140126, Punjab, India

*Corresponding author: E-mail: rksingh244@gmail.com

Abstract

Hantzsch 1,4-dihydropyridine and its derivatives are an important class of bioactive molecules in the pharmaceutical field. The work on this project was started with the objective of synthesizing known 1,4-dihydropyridine by various green chemistry methods like microwave, solvent-free, ultrasonication and compared the results with conventional technique using different aldehydes and 1,3-dicarbonyl compounds as substituents. The twelve known 1,4-dihydropyridines were synthesized and characterized by their TLC, FT-IR and 1H NMR, elemental studies. When all the data cross-examined, it was concluded that microwave, ultrasonic and solvent-free methods were efficient and less time consuming with high yield. At the same time conventional method was time consuming but scalable when compared with other methods.

Keywords

Green chemistry, 1,4-Dihydropyridine, Conventional, Microwave, Ultrasonic, Solvent-free.

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  • Asian J. Chem. /
  •  2012 /
  •  24(12) /
  •  pp 5649-5651