Synthesis, Structural and Biochemical Activity Studies of Symmetrical and Unsymmetrical Pyrroles and their Mononuclear Cu(II), Ni(II) and Co(II) Complexes

E. Senses*, S. Karabocek, N. Karabocek and P. Ekmekcioglu

Department of Chemistry, Karadeniz Technical University, Trabzon 61080, Turkey

*Corresponding author: Fax: +90 462 3253195; Tel: +90 462 3772598; E-mail: serdar@ktu.edu.tr

Abstract

Monomeric copper(II), nickel(II) and Co(II) complexes of 2-(2,5-dimethyl-1H-pyrrol-1- yl)aniline, (dmpyph) and 1,1'-(1,2-phenylene)-bis(2,5-dimethyl-1H-pyrrole) (tmpyph) were prepared and characterized by elemental analyses, magnetic moments, 1H NMR and 13C NMR, IR, mass spectral studies. The mononuclear metal complexes of dmpyph and tmpyph were found to have a 1:2 metal:ligand ratio. Elemental analyses, stoichiometric and spectroscopic data of metal complexes indicated that the metal ions were coordinated to the -NH2 and C=N group nitrogen atoms (C=N). All of the data obtained from spectral studies supported the structural properties of ligands and their metal complexes. The free ligands and their metal complexes showed antimicrobial activity against only S. aureus, but no antifungal activity was observed against yeast like fungi. Among them, copper complexes and free ligands showed a narrow range of inhibitory activity against Mycobacterium smegmatis. Free ligands (1, 2), were found to have activity against Saccharomyces cerevisiae (Sc).

Keywords

Pyrrole, Aniline, Metal complexes, Antimicrobial activity.

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  • Asian J. Chem. /
  •  2012 /
  •  24(9) /
  •  pp 3797-3801