Synthesis and Anticonvulsant Evaluation of (R)- and (S)-3-Carbobenzyloxy-amino-1-oxysuccinimides

Do-Hun Lee

Department of Chemistry, Dong-A University, Busan 604-714, Republic of Korea

Corresponding author: Fax: +82 51 2001053; E-mail: dohlee@dau.ac.kr

Abstract

A series of (R)-and (S)-3-carbobenzyloxy-amino-1-oxysuccinimides (5a-d) [(S)-3-carbobenzyloxy-amino-1-benzoyloxysuccinimde, (R)-3-carbobenzyloxy-amino-1-acetyloxysuccinimde, (R)-3-carbobenzyloxy-amino-1,4-nitrobenzoyloxysuccinimde, (R)-3-carbobenzyloxy-amino-1,4-fluorobenzoyloxysuccinimde] were synthesized and investigated their anticonvulsant activities in maximal electric shock seizure test and pentylenetetrazole induced seizure test.

Keywords

Amino-1-oxysuccinimides, Maximal electric shock seizure test, Pentylenetetrazole induced seizure test, Anticonvulsant activity.

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