Synthesis and Biological Activity of Some 3-Aryl-3,4-dihydro-2H-benz[e]-1,3-oxazines/6-bromo-3-aryl-3,4-dihydro-2H-benz[e]-1,3-oxazines

Davender Kumar Shukla1, Manju Rani1, Arif Ali Khan1,*, Kavita Tiwari2 and Rajinder K. Gupta2

1University School of Basic & Applied Sciences, Guru Gobind Singh Indraprastha University, Sector 16C, Dwarka, New Delhi-110 078, India

2University School of Biotechnology, Guru Gobind Singh Indraprastha University, Sector 16C, Dwarka, New Delhi-110 078, India

*Corresponding author: E-mail: khanaarif@hotmail.com

Abstract

N-(2-Hydroxy)-benzyl-arylamine (1) gives substantially pure 3-aryl-3,4-dihydro-2H-benz[e]-1,3-oxazines/6-bromo-3-aryl-3,4-dihydro-2H-benz[e]-1,3-oxazines (2) on cyclization with formaldehyde in methanol within 0.5-1.0 h at 65-68 ºC in excellent yields. The compounds thus prepared were screened for their antimicrobial studies against Gram-positive bacteria (Staphylococcus aureus, MTCC 96) and Gram-negative bacteria (E. coli, MTCC 739). For estimating antifungal activity the organism used is Candida albicans. Minimum inhibitory concentration of all the compounds was determined using the micro-broth dilution method.

Keywords

Arylamine, Formaldehyde, Benz-1,3-oxazine, Cyclization, Heterocyclic.

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