Preparation of Avermectin Molecularly Imprinted Polymer Microspheres and Their Adsorption Properties

Y. Zhang1,2, Y.Y. Hu3, H.Q. Xu1,2,*, X. Chen1,2 and X.Q. Ji1,2

1Ministry of Education, Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region, College of Animal Science, Guizhou University, Guiyang 550025, Guizhou, P.R. China

2Ministry of Education Key Laboratory of Green Pesticide and Ago-Bioengineering, Guizhou University, Guiyang 550025, Guizhou, P.R. China

3Key Laboratory of Tropical Biological Resources of Ministry of Education, Haikou 570228, Hainan, P.R. China

*Corresponding author: Fax: +86 851 3620938; Tel: +86 851 8292183; E-mail:;


In this study, avermectin molecularly imprinted microspheres have been prepared by high-temperature thermopolymerization under optimized conditions, employing avermectin as a template molecule, 4-vinylpyridine as a functional monomer, divinylbenzene as a crosslinking agent and azobisisobutyronitrile as an initiator. The interaction between functional monomers and template molecules was investigated by UV/visible and infrared spectroscopies and the adsorption properties of molecularly imprinted polymer and control polymer for avermectin were also comparatively analyzed. The results showed that the adsorption capacity of molecularly imprinted polymer for avermectin was significantly higher than that of the control polymer (P < 0.01), which indicated that the molecularly imprinted polymer microspheres prepared by this method had a specific adsorption effect on the template molecule and that the polymer microspheres could be used to detect and analyze avermectin residues.


Adsorption, Avermectin, Microspheres, Molecularly imprinted polymer.

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