Multicomponent One-pot Green Synthesis of 1-Amidoalkyl-2-naphthols Promoted by p-Nitrobenzoic Acid Under Solvent-free Condition

Tiangang Li1,†, Xing Zhai1,†, Dharamveer Singh2, Rajesh K. Singh2,* and Xuegong Xu3,*

1Beijing University of Chinese Medicine, Beijing 100029, P.R. China

2Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal-140 126, India

3Zhengzhou Traditional Chinese Medicine Hospital, Zhengzhou, P.R. China

*Corresponding authors: E-mail: rksingh244@gmail.com; xgxzhengzhou@126.com †Both authors contributed equally to this paper.

Abstract

A series of sixteen 1-amidoalkyl-2-naphthols derivatives were synthesized by one-pot multicomponent condensation reaction of b-naphthol with various aromatic aldehydes and amides under thermal (hot plate and oil bath) and microwave irradiation techniques promoted by p-nitrobenzoic acid and the corresponding products were obtained in good to excellent yield (82-92 %) under solvent-free condition.

Keywords

1-Amidoalkyl-2-naphthol, p-Nitrobenzoic acid, Multicomponent one-pot reaction, Microwave irradiation, Solvent-free.

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