Highly Efficient Zinc Oxide Nanoparticles Catalyzed Green Synthesis of 1,5-Benzodiazepines under Solvent-Free Path

Yuhao Zhao1, Xuejie Yu2, Manpreet Saini3, Yanxu Ma4,* and Rajesh K. Singh3,*

1School of Traditional Chinese Medicine, Capital Medical University, 100069 Beijing, P.R. China

2Beijing University of Chinese Medicine, 100029 Beijing, P.R. China

3Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal-140 126, India

4Department of Orthopedics, Beijing Traditional Chinese Medicine Hospital, Capital Medical University, Beijing 100010, P.R. China

*Corresponding authors: E-mail: rksingh244@gmail.com; yanxumabjtcm@126.com

Abstract

An efficient and simple environment-friendly method for the preparation of substituted 1,5-benzodiazepines as biologically interesting compounds under heterogenous catalyst is described. The one-pot multicomponent condensation of o-phenylene-diamine and substituted ketones catalyzed by zinc oxide nanoparticles (ZnO NPs) under microwave under solvent-free condition has been developed. The present protocol provides a green and improved pathway for the synthesis of 1,5-benzodiazepines in terms of excellent yields, short reaction times and reusability of catalyst.

Keywords

1,5-Benzodiazepines, Zinc oxide nanoparticles, Heterogenous catalyst.

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