A Molecular Imprinted Polymers with b-Cyclodextrin for Adsorption of Paeoniflorin

K.K. Zhao1, W. Zhang1,2,*, H.D. Zhang1, H. Du1, Q. Li1, S.Y. Wang1,2 and Y. Wang1

1School of Chemical Engineering, University of Science and Technology Liaoning, Anshan, Liaoning Province, P.R. China

2Center of Fine Separation, University of Science and Technology Liaoning, Anshan, Liaoning Province, P.R. China

*Corresponding author: Tel: +86 412 5929480; E-mail: askdzw@163.com


b-Cyclodextrin and epichlorohydrin were respectively used as functional monomer and cross-linker to synthesize molecularly imprinted polymers microspheres (MIPs) by suspension polymerization, for adsorption of paeoniflorin (PF), named PF-MIPs. The experiment indicated the PF-MIPs have specific selectivity on paeoniflorin. The paeoniflorin binding site was found inside of PF-MIPs by Scatchard analysis, with Kd and Qmax of 0.46 mg/mL and 47.22 mg/g, respectively. The adsorption process was endothermic process, the adsorption of paeoniflorin on MIPs followed Freundlich adsorption model. The PF-MIPs can be re-used to isolation paeoniflorin at least 10 times.


Molecularly imprinted polymers, Paeoniflorin, Adsorption, b-Cyclodextrin.

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