Synthesis of Ibuprofen-Molecularly Imprinted Polymers Used as Sensors to Determine Drug in Pharmaceutical Preparations

Yehya Kamal Al-Bayati* and Fadhel Ibrahem Aljabari

Chemistry Department, College of Science, Baghdad University, Al-Jaderia, Baghdad, Iraq

*Corresponding author: E-mail: yahyaalbayti@yahoo.com

Abstract

Two molecularly imprinted polymers (MIPs) were prepared by using ibuprofen as the template as well as methacrylic acid (MAA) or acrylamide (ACY) as monomer, used ethylene glycol dimethacrylate (EGDMA) or trimethylol propane triacrylate (TMPTA) as cross linker and benzoyl peroxide as initiator. Non-imprinted polymers (NIPs) prepared by using the same composition of MIPs except the template (ibuprofen). The membrane of MIPs and NIPs were prepared by using dibutyl phthalate (DBPH), oleic acid (O.A), paraffin (PRF) and o-nitro phenyloctyl ether (ONPOE) as plasticizers in PVC matrix. The slope, detection limit, linearity range of electrodes MIPs from (-54.25, -45.23) mV/decade, (1.09 × 10-6 M to 9 × 10-6 M) and (1 × 10-5 to 1 × 10-1), respectively. Stable response of pH range from (3.5-7.5) and the selectivity with inorganic ions (Na+, Li+, Ca2+, Mg2+, Fe3+ and Al3+) show good selectivity.

Keywords

Molecularly imprinted polymers, Ibuprofen, Ion selective electrode, Different plasticizers.

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