Microwave Promoted Y(NO3)3·6H2O Catalyzed Biginelli Synthesis of Dihydropyrimidin-2-ones

A.A. Khan, K. Mitra and M.A. Mondal*

Department of Chemistry, University of Gour Banga, Malda-732 103, India

*Corresponding author: E-mail: mohabul.mondal@gmail.com


Biginelli synthesis of 3,4-dihydropyrimidinones from aldehydes, b-keto ester and urea using yttrium nitrate hexahydrate, as an efficient catalyst are demonstrated under microwave condition. This method offers significant advantages, such as high yields, short reaction times, easy isolation and mild reaction conditions. We have also investigated mechanism of Y(NO3)3 catalyzed 3,4-dihydropyrimidinones synthesis and identified the key intermediate benzal-bisurea by LC-MS.


Biginelli reaction, Yttrium nitrate, Dihydropyrimidinones, Multicomponent reaction, Mechanistic study.

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