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Isolation of Two New Cheilanthane-Type Tricarbocyclic Sesterterpenoids from Leaves of Caesalpinia crista Linn.: A Traditionally Used Antimalarial Plant of Assam, India

Kamaruz Zaman1,*, Dipak Chetia1 and Mohammed Ali2

1Department of Pharmaceutical Sciences, Dibrugarh University, Dibrugarh-786 004, India

2Department of Pharmacognosy and Phytochemistry, Faculty of Pharmacy, Jamia Hamdard, New Delhi-110 062, India

*Corresponding author: E-mail: z_kamar2003@yahoo.com

Abstract

Caesalpinia crista L. (family Caesalpiniaceae) is a large scandent prickly evergreen shrub widely distributed in south-eastern Asia, Nigeria and Pacific region. The leaves are useful to cure skin infections, sore throat, intestinal worms, hepatic disorders, malaria and leprosy. Phytochemical investigation of a methanolic extract of the leaves of C. crista afforded two new cheilanthane-type tricarbocyclic sesterterpenoids characterized as 4a,4b,8b,13b-tetramethyl-14-(17-methyl-pent-14-enyl)-perhydrophenanthrene-11a-ol-22-oic acid (1, cristasesterterpenoic acid) and 4a,4b,8b,10b,13b- pentamethyl-14-(-17-methylpent-14-enyl)-perhydrophenanthrene-3b-olyl-O-b-D-glucopyranoside (2, cristasesterterpinol glucoside). The structures of these compounds were elucidated on the basis of spectral data analysis and chemical reactions.

Keywords

Caesalpinia crista, Leaves, Cristasesterterpenoic acid, Cristasesterterpenol glucoside.

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