An Improved Process for Preparation of Dabigatran Etexilate Mesylate

Sd. Khasim Sharif, B. Sri Ramudu, Rambabu Nunna and D. Ramachandran*

Department of Chemistry, Acharya Nagarjuna University, Nagarjuna Nagar, Guntur-522 510, India

*Corresponding author: E-mail:


An improved process for the preparation of dabigatran etexilate mesylate, wherein the process is substantially free to eliminates the potential impurities. The impurities are formed due to presence of contaminated starting ingredients that is present in commercially available n-hexyl chloro formate. The present invention is to control impurities by using pure n-hexanol in place of n-hexyl chloro formate. Over all yields is good and process can’t requires expensive catalysts. Dabigtran is used to prevent strokes in those with arterial fibrillation due to heart valve causes, as well as deep venous thrombosis (DVT). Moreover, the present invention is providing simple, industrial scalable and cost-effective process, which affords good quality and yield.


Deep venous thrombosis, Arterial fibrillation, Contaminated, Substantially.

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