Comparative in silico and in vivo Analgesic and Anti-Inflammatory Activities of Some Novel Schiff Bases of Isatin

P.P. Chinchole1,* and S.B. Wankhede2

1Department of Chemistry, Dr. D.Y. Patil Institute of Pharmaceutical Sciences & Research, Pimpri, Pune-411 018, India

2Department of Chemistry, J.S.P.M's Charak College of Pharmacy and Research, Wagholi, Pune-412 207, India

*Corresponding author: E-mail: pavanchinchole@gmail.com

Abstract

The objective of this study is to synthesize the different derivatives of isatin and pyrazole on Schiff base mechanism, which on subjected to docking study by AUTODOCK TOOL software. in vitro and in vivo analgesic and anti-inflammatory activities were performed on the compound showing the optimum docking results selected on the basis of binding energy.

Keywords

Isatin, Pyrazole, Schiff base, Analgesic activity, Anti-inflammatory activity, Docking study.

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