Di-cationic Ionic Liquid Catalyzed Synthesis of 1,5-Benzothiazepines

Raghavendra Sakirolla1,*, Krishnaji Tadiparthi2, Marzieh Yaeghoobi3 and Noorsaadah Abd. Rahman3

1Department of Chemistry, Central University of Karnataka, Kadaganchi, Aland Road, Kalaburagi-585 367, India

2Department of Chemistry, Christ University, Hosur Road, Bangalore-560 029, India

3Department of Chemistry, University of Malaya, 50603, Kuala Lumpur, Malaysia

*Corresponding author: E-mail: srgoud2@gmail.com


A simple and elegant method for the synthesis of 1,5-benzothiazepines has been developed using di-cationic liquid as a solvent cum catalyst by the reaction of o-aminothiophenol with a variety of chalcones under mild reaction conditions. Furthermore the reusability of the catalyst has also been studied for three cycles. All the reactions are proposed to proceed through a 1,4-conjugate Michael addition followed by a cyclo-condensation reaction.


gem-Dicationic ionic liquids, 1,5-Benzothiazepines, 1,5-Benzodiazepines, Cyclo-condensation reaction, Reusability.

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