Antimicrobial Activity of Cu(II) and Fe(III) with Pyridine Complexes as Ligands Contrary to Clinical Strains of Bacteria and Fungi Species

Faridul Islam1,2,, Jannat Al Foisal3, Mahbubur Rahman3,4,*, Md Zahidul Islam5,, Mst. Afsana Mimi6, Rasel Habib3,, Md. Amran Hossain7, Likson Chowdhury8, Sreebash Chandra Bhattacharjee9 and Daxiang Cui4

1Institute of Food Science and Technology, Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka-1205, Bangladesh

2Department of Chemical Engineering, University of Newcastle, Callaghan, NSW-2308, Australia

3Department of General Educational Development (GED), Faculty of Science and Information Technology, Daffodil International University, Mirpur Road, Dhanmondi, Dhaka 1207, Bangladesh

4Institute of Nano Biomedicine and Engineering, Shanghai, Engineering Research Center for Intelligent Instrument for Diagnosis and Therapy, Department of Instrument Science & Engineering, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P.R. China

5Department of Chemistry, Sakarya University, Esentepe Campus-54187, Turkey

6Department of Applied Chemistry & Chemical Engineering, Faculty of Engineering & Technology, Islamic University, Kushtia-7003, Bangladesh

7Department of Chemistry, Chittagong College, Chittagong, Bangladesh

8Upazila Family Planning Office, Rouzan-4340, Bangladesh

9Bangladesh Council of Scientific and Industrial Research (BCSIR) Laboratories Chittagong, Chittagong-4220, Bangladesh

*Corresponding author: Tel: +88 02 9138234 (Ext: 232); E-mail: mahbub_iuchem@yahoo.com

Abstract

In this study, green coloured Cu(II) and red coloured Fe(III) complexes of pyridine were prepared and the elemental characterization confirmed their composition. The pyridine complexes of Cu(II) and Fe(III) were found very interesting and attractive as potential candidates with antimicrobial activity. Along with this, melting point, molar conductivity measurement, magnetic moment determination, electronic and FTIR spectroscopy were also measured to characterize the prepared complexes. Pyridine acts as monodentate which resulted in formation of square planar and octahedral structure of Cu(II) and Fe(III) complexes, respectively with the nitrogen atom pyridine ring by coordination bond. For antimicrobial activity studies Alternaria alternata, Bacillus cerelus, Botrgodiplodia theobromal, Colletotrichums corcolei, Escherichia coli, Fusarium equiseti, Macrophomina phaseolina, Salmonell typhi and Shigella dysenteriae were used. The prepared complexes showed inhibition against mycelial growth. Although the complexes showed satisfactory inhibition against the tested bacteria and fungi species, both of the complexes were comparatively better against bacteria than fungi compared to ligand.

Keywords

Transition metal (II) complexes, Square planar, Octahedral structure, Pyridine, Microbial activity.

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