Isolation of Steroid Compounds from Randia malabarica (Triveng) and their Biological Activity

M. Shanthamani and R. Ulagi*

PG & Research Department of Chemistry, Government Arts College (Autonomous), Coimbatore- 641018, India

*Corresponding author: E-mail: shanthache@gmail.com; ratnamulagi15@gmail.com

Abstract

Two steroidal compounds i.e., 1-octacosanol (1) and β-sitosterol (2) were isolated from ethyl acetate fraction of Randia malabarica (Triveng). The antitumor activity of the compounds 1 and 2 were observed against A549 and HeLa using MTT assay. The isolated compounds exhibited a strong inhibitory effect on the two cancer cell lines with a significant effect of inhibition. Molecular docking studies have been performed for both the compounds, showed good inhibitory activity, thereby opening its applications to various clinical trials.

Keywords

1-Octacosanol, Randia malabarica, Molecular docking, Antimicrobial activity, Antitumor activity.

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