Microwave Assisted Synthesis and Antimicrobial Activity of 1-(2-Chloropyridin-3-yl)-3-substituted Urea Derivatives

Vijay Kumar Pujari1,*, Srilalitha Vinnakota2, Ramana Kumar Kakarla3 and Sridhar Marojua1

1New Age Life Science, Plot No. 65A&B, Sy. No. 125, Road No. 28, IDA Phase-II, Mallapur, Hyderabad-500076, India

2Department of Chemistry, Faculty of Science and Technology, ICFAI Foundation for Higher Education, Hyderabad-501203, India

3Department of Chemistry, CMR Institute of Technology, Hyderabad-501401, India

*Corresponding author: E-mail: pujarivijaykumar7@gmail.com


A green one pot synthetic protocol method for 1-(2-chloropyridin-3-yl)-3-substituted urea derivatives from 2-chloropyridin-3-amine and tert-butyl substituted carbamates by using bis(trimethylaluminum)-1,4-diazabicyclo[2,2,2]octane (DABAL-Me3) under microwave irradiation is developed. The compound structures established by spectral data such as IR, 1H NMR and mass spectroscopy. All the synthesized compounds were tested in vitro antimicrobial activity.


2-Chloropyridinyl urea derivatives, Microwave irradiation method, Antimicrobial activity.

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