Microwave Assisted Synthesis and Antimicrobial Activity of 1-(2-Chloropyridin-3-yl)-3-substituted Urea Derivatives

Vijay Kumar Pujari1,*, Srilalitha Vinnakota2, Ramana Kumar Kakarla3 and Sridhar Marojua1

1New Age Life Science, Plot No. 65A&B, Sy. No. 125, Road No. 28, IDA Phase-II, Mallapur, Hyderabad-500076, India

2Department of Chemistry, Faculty of Science and Technology, ICFAI Foundation for Higher Education, Hyderabad-501203, India

3Department of Chemistry, CMR Institute of Technology, Hyderabad-501401, India

*Corresponding author: E-mail: pujarivijaykumar7@gmail.com

Abstract

A green one pot synthetic protocol method for 1-(2-chloropyridin-3-yl)-3-substituted urea derivatives from 2-chloropyridin-3-amine and tert-butyl substituted carbamates by using bis(trimethylaluminum)-1,4-diazabicyclo[2,2,2]octane (DABAL-Me3) under microwave irradiation is developed. The compound structures established by spectral data such as IR, 1H NMR and mass spectroscopy. All the synthesized compounds were tested in vitro antimicrobial activity.

Keywords

2-Chloropyridinyl urea derivatives, Microwave irradiation method, Antimicrobial activity.

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