Green Synthesis Approaches of 2-Bromo-4-methyl thiazole-5-carboxamide Derivatives as Potent Microbial Agents

Jeevanreddy Miryala, Mahesh Morthad and Satyanarayana Battu*

Department of Chemistry, Osmania University, Hyderabad-500007, India

*Corresponding author: E-mail: satyambchem@yahoo.co.in

Abstract

As a part of our ongoing research in the development of new, selective and environmental friendly methodologies, herein we report a new series of 2-bromo-4-methylthiazole-5-carboxamide derivatives using polyethylene glycol-400 (PEG-400) as a solvent. All the newly synthesized compounds were screened to their in vitro antimicrobial activities and all the compounds exhibited remarkable growth inhibition of wide spectrum of Gram-positive bacteria and Gram-negative bacteria. Molecular docking was done performed computational software GOLD (Genetic algorithm based, flexible ligand, partial flexibility for protein).

Keywords

Thiazole, PEG-400, Antimicrobial activity, Docking

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