Kinetics and Mechanistic Investigation of Ru(III) Catalyzed Oxidative Degradation of Linezolid by Permanganate at Environmentally Relevant pH

Vijaykumar S. Bhamare* and Raviraj M. Kulkarni

Department of Chemistry, KLS Gogte Institute of Technology (Autonomous), (Affiliated to Visvesvaraya Technological University), Belagavi-590008, India

*Corresponding author: E-mail: vbhamare37@gmail.com

Abstract

The influences of [permanganate], [linezolid], [Ru3+], pH, temperature, ionic strength, solvent polarity, etc. on the rates of uncatalyzed and Ru3+ catalyzed oxidative degradation of linezolid by Mn7+ were investigated at environmentally relevant pH. The increase in [permanganate], [linezolid] and temperature increases the rates of uncatalyzed and catalyzed reactions. It is observed from the calculated pH dependent second order constants that the rate of reaction decreases with increase in pH from 3.0 to 9.0. The values of apparent second order rate constants are 12 times faster in the presence of Ru3+. Four degraded products of linezolid were identified with the help of HR-MS data. Based on kinetic and HR-MS data, a plausible catalytic mechanism was proposed. In this mechanism, Ru3+ acts as an electron shuttle and was oxidized by Mn7+ to the higher oxidation states of ruthenium such as Ru6+ and Ru7+. Activation parameters were determined and discussed.

Keywords

Ru3+ Catalysis, Linezolid, Permanganate, Kinetics, Water treatment, Degradation

   View Article PDF File Under a Creative Commons License