Schiff Base Metal Complexes as Anticancer Agents

G. Sridevi1,2,*, , S. Arul Antony3 and R. Angayarkani1

1Department of Chemistry. Sriram Engineering College, Chennai-602024, India

2R&D Centre, Bharathiar University, Coimbatore-641046, India

3PG and Research Department of Chemistry, Presidency College, Chennai-600005, India

*Corresponding author: E-mail: sridevi.lec@gmail.com

Abstract

Cutting-edge practices in bioinorganic chemistry are pivotal for enhancing the layout of compounds to lessen poisonous facet effect and recognize their mechanism of action. A powerful anticancer agent should own inherent, inhibitory property and also delivery, dosage and residence time in vivo. Organic function and conformation of mutated gene may be altered by way of binding of metal ions. Upswing of activities counting on the structural data, intending in enhancing and growing different forms of metal based compounds, continuous seek of extra metal based compounds have been synthesized via revamping the prevailing chemical shape via ligand substitution. The prevailing paper addresses the trendy development in the design of novel antitumor agents primarily based on transition metal complex via highlighting the near dating among their structural alternatives and cytotoxic ability.

Keywords

Schiff base, Mutated gene, Antitumor agents, Cytotoxic ability.

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