Preparation and Characterization of New Carrier Drug Polymers Based Maleimide and Its Drug Release Behaviour

Fatimah Abdul Razzak Mageed1, Mohanad Musa Kareem2,*, and Mohammad N. Al-Baiati1

1Department of Chemistry, College of Education for Pure Sciences, University of Kerbala, Kerbala, Iraq

2Department of Chemistry, College of Sciences, University of Babylon, Babylon, Hilla, Iraq

*Corresponding author: E-mail: mohanad_1972@yahoo.com; mohammad.nadhum@uokerbala.edu.iq

Abstract

In this work, two new drug substituted monomers and new homogenous and heterogeneous polymers were synthesized loaded with medicinal properties to extend the controlled drug. The first step includes preparation of compound (F1) via reaction of maleic anhydride with 4-aminobenzoic acid. Then compound (F1) was converted to its corresponding acyl chloride derivative which reacted with amino drugs (sulfadiazine, chlordiazepoxide) afforded (F2 and F3) monomers. Homogeneous polymers (F8 and F9) prepared through polymerization reaction of free radicals of the monomers (F2 and F3) under nitrogen using methyl ethyl ketone peroxide (MEKP) as initiator. Heterogeneous polymers (F14 and F15) prepared through polymerization reaction of free radicals of the monomers (F2 and F3) separately with acrylic acid under nitrogen using methyl ethyl ketone peroxide (MEKP) as initiator. All these prepared monomers and polymers were characterized by FT-IR and 1H NMR, 13C NMR spectroscopies. Controlled drug release and swelling % was studied in different pH values at 37 ºC. Intrinsic viscosities were measured at 25 ºC with Ostwald viscometer and applied the characteristic of solubility for these polymers.

Keywords

Maleimide, Copolymer, Sulfadiazine, Chlordiazepoxide, Drug delivery system

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