Studies and Synthesis of Substituted 4-Biphenyl Acetamide Derivatives

Anju Khullar

Department of Chemistry, General Shivdev Singh Diwan Gurbachan Singh Khalsa College, Patiala-147001, India

Corresponding author: E-mail: anjukhullar9@gmail.com

Abstract

A new series of substituted 4-biphenylamides have been synthesized by condensation of 4-biphenyl acetic acid with different primary amines (aromatic and aliphatic). 4-Biphenyl acetic acid was first treated with thionyl chloride in dry benzene to prepare substituted 4-biphenyl acetyl chloride, which is then treated with different aliphatic or aromatic amines to synthesize various substituted 4-biphenyl acid-amide derivatives. The structure of newly synthesized compounds has been established by analytical and spectral methods. These synthesized compounds have shown antifungal properties against Fusarium udum and Curvularia lunata.

Keywords

Synthesis, 4-Biphenyl acetic acid, Substituted 4-biphenyl acid amides, Antifungal properties.

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