Self Emulsifying Drug Delivery System: A Recent Approach

Sabitri Bindhani1,*, S. Mohapatra1 and R.K. Kar2

1School of Pharmaceutical Sciences, Siksha 'O' Anusandhan University, Khandagiri, Bhubhaneswar- 751030, India

2Department of of Pharmaceutical Sciences, Dadhichi College of Pharmacy, Cuttack-754002, India

*Corresponding author: E-mail: sabitribindhani@soa.ac.in

Abstract

In recent years, nearly 40 % newer drugs compounds are hydrophobic in nature, which is a major challenge now-a-days for oral drug delivering due to low aqueous solubility. Lipid based drug delivery system is one of the favourable approach for poorly soluble compounds which can improve the drug absorption and oral bioavailability. Due to ion-pairing with appropriate surfactant and co-surfactant the macromolecular drug molecular oil droplet being found in the gut flow oral absorption which sufficiently stable towards lipase. Due to the formation of emulsified drug in micron level, it can efficiently endow the oral bioavailability. Several comprehensive papers have been published in the literature illustration diverse type of lipid based formulation with recent advancements. This article is based on an exhaustive and updated review on newer technology which out line an explicit discussion on its formulations and industrial scale up.

Keywords

Lipid, Drug delivery system, Supersaturable self-emulsifying, Solidification technique, Poorly soluble drugs.

   View Article PDF File Under a Creative Commons License