Antarvedisides A-B from Manglicolous Lichen Dirinaria consimilis (Stirton) and their Pharmacological Profile

Vinay Bharadwaj Tatipamula1,, Girija Sastry Vedula1,*, and A.V.S. Sastry2

1Pharmaceutical Chemistry Department, AU College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530003, India

2Pharmacology Department, Maharajah’s College of Pharmacy, Phoolbaugh, Vizianagram-535002, India

*Corresponding author: Tel: +91 891 2844926; E-mail: vgirijasastry@yahoo.co.in

Abstract

The chemical examination of acetone extract of Dirinaria consimilis resulted in isolation of six depsides of which two novel metabolites namely antarvediside A (1) and antarvediside B (2) and four known metabolites i.e. sekikaic acid (3), atranorin (4), divaricatic acid (5) and 2’-O-methyl divaricatic acid (6). From the pharmacological screening of the isolates (1-6), it was found that 1 and 2 exhibited better inhibition of ABTS and superoxide free radicals than that of the standard and compound 4 showed significant inhibition of protein denaturation with IC50 value of 390 mg/mL with respect to indomethacin with 110 mg/mL. From the SRB assay results, the better IC50 values was determined by compound 2 of 10.5, 11.50 and 12.50 μg/mL on HeLa, MCF-7 and FADU cancer cell lines, respectively. Thus, the outcomes revealed that the D. consimilis is a new source to treat free radicals, inflammation and cancer.

Keywords

Antioxidant, Protein denaturation, Inflammation, Cancer, Sulforhodamine B assay.

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