Synthesis, Characterization and Biological Evaluation of Isoxazoles Derived from 3-Aminoacetophenone

T. Raj Kumar1,*, S.V. Suresh Kumar2 and N. Srinivasan3

1Department of Pharmaceutical Chemistry, Creative Educational Society’s College of Pharmacy, Kurnool-518218, India

2Department of Pharmacognosy, Creative Educational Society’s College of Pharmacy, Kurnool-518218, India

3Department of Pharmacognosy, Annamalai University, Annamalainagar-608002, India

*Corresponding author: E-mail: rajkutty1983@gmail.com

Abstract

Isoxazoles were synthesized by condensing different aldehydes with 3-aminoacetophenone coupled to N-methyl piperazines. All the compounds were screened for anticancer activity against human breast cancer cell lines- MCF-7 and MDA-MB-468. The antimycobacterial activity of compounds were assessed against M. tuberculosis using microplate alamar blue assay (MABA). The structures of newly synthesized compounds established on the basis of their m.p., TLC, FTIR, mass and 1H NMR data. The results of antimycobacterial and anticancer studies shows that some of it posses mild to moderate activity against standard. These new synthesized compounds were identified and characterized, demonstrated antitubercular, in vivo efficacy in tumor models like MCF-7 and MDA-MB-468.

Keywords

Isoxazoles, 3-Aminoacetophenone, MCF-7, MDA-MB-468.

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