Synthesis of Sulfonated Dihydrofuropyrazoles Derivatives as Antimicrobial Active Agents

Venkata Swamy Tangeti* and K.V.V.V. Satyanarayana

Department of Chemistry, Dr. Sarvepalli Radha Krishnan Government Arts College (Pondicherry University), Yanam-533464, India

*Corresponding author: E-mail: swamychempcu@gmail.com

Abstract

A series of sulfonyl dihydrofuropyrazole derivatives was prepared from one pot multi component condensation of sulfonated β-keto ester, aromatic aldehyde, hydrazine, pyridinium ylide in presence of piperidine catalyst under ethanol solvent conditions and subsequent oxidation of SPh group with MCPBA. All the synthesized compounds were characterized by analytical and spectral techniques and screened in vitro for antimicrobial activity. The activity data revealed that most of the compounds exhibited good to significant activities. Compounds 6b, 6i, 6j, 6k, 6m, 6n exhibited good and broad spectrum activity towards all the tested bacterial strains.

Keywords

Sulfonated dihydrofuropyrazole, Phenylthio β-keto ester, Blaise reaction, Antimicrobial activity.

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