Synthesis, Characterization and Biological Studies of Novel Schiff Base viz. Bis-1,1'-(pyridine-2,6-diyldieth-1-yl-1-ylidene) biguanidine and Their Transition Metal Complexes

Manoj Kumar1,*, Pallvi1, Hardeep Singh Tuli2 and Rajshree Khare3

1Department of Chemistry, Maharishi Markandeshwar University, Sadopur-Ambala-134007, India

2Department of Biotechnology, Maharishi Markandeshwar University (Deemed to be University), Mullana-Ambala-133207, India

3Department of Chemistry, Maharishi Markandeshwar University (Deemed to be University), Mullana-Ambala-133207, India

*Corresponding author: E-mail: manojraju27@gmail.com

Abstract

Novel Schiff base and its two transition metal complexes derived from the condensation reaction of 2,6-diacetylpyridine with biguanide, characterized by 1H NMR, IR and elemental analysis. The ligand and its cobalt(II) and nickel(II) complexes showed potent DNA photo-cleavage activity. Antimicrobial activity of this Schiff base and its cobalt(II) and nickel(II) complexes against bacteria and fungi viz. S. aureus, K. pneumoniaae and A. niger, Trichophyton rubrum, respectively was evaluated in terms of zone of inhibition.

Keywords

Cobalt(II), Nickel(II), Complexes, 2,6-Diacetylpyridine, Biguanide, DNA Photo-cleavage.

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