Insights into the Origin, Transmission and Outbreak of Coronavirus Disease (Covid 19): A Recent Study: A Review

Jhilam Majumder1, Subhadeep Das1 and Shubhasis Dan2,*

1Department of Life Science and Biotechnology, Jadavpur University, Jadavpur-700032, India

2Department of Pharmaceutical Science & Technology, Maulana Abul Kalam Azad University of Technology, NH-12, Haringhata, Nadia- 721249, India

*Corresponding author: E-mail: subhasisdan@gmail.com

Abstract

Present pandemic situation due to the appearance of COVID-19 has put the world in a miserable condition. More than 2.5 million people have been infected with the causal strain of coronavirus SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2). The first case of COVID-19 infection was reported in China in December 2019. Scientists are searching the effective tool to combat this virus. The study has been undertaken by the scientists towards finding effective medicine, vaccine as well as robust techniques to detect this virus. Besides development of new treatment, the application of clinical data analytics has also been observed for the off-label use of the already available medications. As a part of the real time application of science and technology, several clinical trials has been in process to extract the best answer against COVID-19. In present article, a comprehensive review has been carried out to conscripting the available knowledge about discovery, genomic structure, mechanism of infection and clinical features of SARS-CoV-2. Presently available procedures for detection of this virus have been highlighted. Besides these, available treatments which have been explored by the researchers worldwide, includes precisely convalescent plasma therapy, monoclonal antibody therapy as well as antiviral medications along with their regulatory status, have been discussed elaborately which will definitely enrich the global understanding as well as proficient ability to combat this pathogens.

Keywords

COVID-19, SARS-CoV-2, SARS-CoV, MERS-CoV, Genomic architecture, Pathogenesis, Transmission, Therapy.

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