One Pot Synthesis of Schiff Base Complexes of Cu(II), Zn(II), Ni(II), Co(II) and their Cytotoxicity, Molecular Docking and Antibacterial Activity

A. Ashma1,2, A. Sudha2, S.L. Ashok Kumar3, G. Sasikumar2 and S.J. Askar Ali2,*

1Department of Chemistry, Aalim Muhammed Salegh College of Engineering, Avadi-IAF, Chennai-600055, India

2PG and Research Department of Chemistry, The New College (Autonomous), Chennai-600014, India

3Department of Chemistry, GRT Institute of Engineering and Technology, Thiruthani, Chennai-631209, India

*Corresponding author: E-mail: askaralisj@gmail.com

Abstract

A novel Schiff base ligand (L), N(4)-cyclohexyl-2-(1-(5-chlorothiophen-2-yl)ethylidene)hydrazine carbothioamide was synthesized from isothiocyanatocyclohexane and hydrazine. All the synthesized transition metal(II) complexes were characterized by functional peak using 1H NMR, 13C NMR, FT-IR, UV-vis spectroscopy and metal complex atomic ratio of complexes of thiosemicarbazones were characterized by elemental analysis. Schiff base and its metal(II) complexes were screened in vitro medicinal drug activity against Gram positive and Gram-negative microorganisms and anti-cancer activity against human carcinoma cell line MCF-7 was detected with nickel(II) and cobalt(II) complexes. Further, the cytotoxity of ligand and its metal(II) complexes were tested on a Monkeys normal cell line and found to be non-toxic (< 200 μg/mL). In the present work, the molecular mechanism of anticancer (breast cancer) activity of the compounds were also disscussed.

Keywords

Schiff base ligand, Thiosemicarbazone, Metal complexes, Antibacterial screening, Cytotoxicity activity.

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