Novel Commercial Scale Synthetic Approach for 5-Cyanoindole: A Potential Intermediate for Vilazodone Hydrochloride, an Antidepressant Drug

M. Venkatanarayana1,*,, Ravi Nuchu1,2, H. Sharath Babu1, Ganga Sravanthi Garrepalli3 and Sudhakar Tangallapall4

1Department of Chemistry, GITAM School of Science, GITAM (Deemed to be University), Hyderabad-502329, India

2Mylan Laboratories Ltd, Bollaram Industrial Area, Hyderabad-502325, India

3Trinity College Pharmacy, Peddapalli-505172, India

4Department of Chemistry, Kakatiya Institute of Technology & Science, Warangal-506015, India

*Corresponding author: E-mail:


Present work describes the synthesis of 5-cyanoindole, a common intermediate used in various synthetic route of the antidepressant vilazodone hydrochloride. The protocol is both robust and commercially viable, utilizing readily available and low-cost materials and the isomers are environmental friendly than previously reported routes through its evading use of cyanide reagents and heavy metals.


5-Cyanoindole, Vilazodone hydrochloride, Ring closer reaction.

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