Ultrasound Assisted Synthesis of 1,5-Disubstituted Pyrazole using Cu(I) Catalyst

Ashok S. Pise1, Arvind S. Burungale2,* and Santosh S. Devkate2

1Department of Chemistry, Dada Patil Mahavidyalaya, Karjat-414402, India

2Department of Chemistry, S.M. Joshi College, Hadapsar, Pune-411028, India

*Corresponding author: E-mail: ashokpise67@gmail.com


A new efficient and convenient approach towards the synthesis of pyrazole is described. The α,β-unsaturated cyanoesters were obtained from substituted benzaldehyde and ethyl cyanoacetate by reported methods. 1,5-Disubstituted pyrazoles were synthesized from α,β-unsaturated cyanoester and phenyl hydrazine using sodium ethoxide as a base in the presence of 10 mol % Cu(I) catalyst in high yields within 75-90 min under ultrasound irradiation at 60 ºC. The reaction rate is enhanced tremendously under ultrasound irradiation as compare to conventional methods with improved yields are recorded.


Cyanoester, Cu(I) catalyst, Phenyl hydrazine, Pyrazole, Ultrasound irradiation.

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