Synthesis, Spectroscopic, Thermal and in vitro Antimicrobial Activity of Fe(III) and Mn(III) Metal Complexes of Semicarbazone

Chintan P. Somaiya1,*,, Dinesh S. Patel1 and Darshan H. Jani2

1Shree P.M. Patel Institute of Post Graduate Studies and Research in Science (Affiliated to Sardar Patel University, V.V. Nagar), Anand-388001, India

2Department of Chemistry, Om Science College, Junagadh-362001, India

*Corresponding author: E-mail: somaiyachintan11@gmail.com

Abstract

In this work novel pyrazolone based semicarbazone derivatives and their spectroscopic and biological activities were investigated. Pyrazolone based semicarbazone ligands and their Fe(III) and Mn(III) heterochelates were synthesized. The structure of semicarbazone ligands were confirmed by 1H NMR, IR, elemental analysis and their heterochelates were confirmed by thermal studies (TGA/DTG & DSC) and FAB mass spectroscopy. All the ligands and heterochelates were screened for antimicrobial study against Gram positive (Bacillus megaterium, Bacillus subtilis) and Gram negative (E. coli, Klebsiella) microorganisms. The results confirmed that semicarbazone based heterochelates have a great potential and significant for further investigation.

Keywords

Pyrazolone, Schiff base, Semicarbazone, Antimicrobial screening, Thermal Studies, Transition metal complexes.

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