Synthesis of Selective Bioactive Pyridylpyridones: in silico Studies and Biological Evaluations

Suresh Ramasamy1,2, Singanan Ponnuchamy1,* and Sivakumar Ponnusamy2

1Alivira Animal Health Ltd, R & D Center, Visakhapatnam-530019, India

2Department of Chemistry, Arignar Anna Government Arts College, Namakkal-637002, India

*Corresponding author: E-mail: ponnuchamy_85@yahoo.co.in

Abstract

Twenty three substituted pyridylpyridones were designed and performed for molecular docking studies against α-amylase enzyme. The top three hit molecules were synthesized and characterized by 1H NMR, 13C NMR, ESI-mass and FT-IR spectroscopic techniques. Experimental biological applications were studied for these compounds. The DFT calculations were executed for the hit compounds. In addition, molecular electrostatic potential mapping was also executed for additional support.

Keywords

Pyridines, Anti-diabetic, Molecular docking, DFT studies, Molecular electrostatic map potential.

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