Spectral Studies and Antibacterial Activity of Vanadium(III) Complexes of Heterocyclic Hydrazones

D. Kasimbi1,, K. Hussain Reddy1,*, and N. Devanna2,

1Department of Chemistry, Sri Krishnadevaraya University, Anantapuramu-515003, India

2Department of Chemistry, Jawaharlal Nehru Technological University, Anantapuramu-515002, India

*Corresponding author: E-mail: khussainreddy@yahoo.co.in

Abstract

Vanadium(III) complexes having the composition VLCl3 [where L = 2-acetylpyridine acetoylhydrazone (APAH), 2-acetylpyridine benzoylhydrazone (APBH), 2-acetylthiophene acetoylhydrazone (ATAH) and 2-acetylthiophene benzoylhydrazone (ATBH)] have been investigated using physico-chemical and analytical techniques. Molar conductivity data suggested that the complexes are neutral. Structures of all the vanadium(III) complexes are determined based on infrared and UV-visible spectral data. Electronic spectra of vanadium(III) complexes show three peaks suggesting octahedral structure. Comparison of vibrational spectra of hydrazones and complexes suggest that the hydrazones act as neutral tridentate ligands. The ligands and their vanadium derivatives are screened for their bacteria destroying activity against pathogenic bacterial strains viz. Gram-negative E. coli, Gram-positive Bacillus, Gram-positive Staphylococcus aureus and Gram-negative P. aureoginosa. Bacteria destroying activities of present complexes are comparable to the activity of the streptomycin. Complexes show more activity than their respective ligands in the case of Gram-positive Bacillus and Gram-negative P. aureoginosa.

Keywords

Synthesis, Characterization, Vanadium(III) complexes, Heterocyclic hydrazones, Antibacterial activity.

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