Design, Synthesis and Characterization of Pyrimidine based Thiazolidinedione Derivatives

Vijay Kumar Sharma1,2, Anup Barde2,* and Sunita Rattan1,*

1Amity Institute of Applied Sciences, Amity University Uttar Pradesh, Noida-201313, India

2Integral Bio Sciences Pvt. Ltd. C-64, Hosiery Complex, Phase-II, Noida-201306, India

*Corresponding authors: E-mail: srattan@amity.edu; anup.barde@ibs.net.in

Abstract

Novel thiazolidine-2,4-dione (TZD) based pyrimidine derivatives have been synthesized by Knoevenagel condensation reaction between thiazolidine-2,4-dione and amino pyrimidinyl aliphatic aldehydes followed by heterogeneous metal reduction. Synthetic strategy involved nucleophillic substitution of hydroxyl protected six membered aliphatic chain on 4,6-dichloropyrimidine followed by Suzuki coupling. This approach is regioselective, efficient and versatile for synthesis of such analogs.

Keywords

Thiazolidine-2,4-dione, Suzuki coupling, Knoevenagel condensation.

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