DNA Binding Potency and Antimicrobial Analysis of New Indole and Pyrazolone Based Transition Metal(II) Complexes

Murugan Selvamariammal1,*, and Maruthappan Malarvizhi2,

1Department of Chemistry, Sri S. Ramasamy Naidu Memorial College, Sattur-626203, India

2Research Department of Chemistry, The Madura College, Madurai-625011, India

*Corresponding author: E-mail: selvamariammal23384@gmail.com

Abstract

Some novel series of 5-chloro isatin and 4-aminoantipyrine based Schiff bases with transition metal(II) complexes of (Cu, Co, Ni and Zn) have been prepared and characterized by physical, analytical and spectral data. The synthesized ligand behaves as a neutral tridentate is confirmed by spectral techniques. During the complexation, the stoichiometry ratio 1:2 (metal:ligand) is followed and an octahedral arrangement is adopted by all the metal complexes. The calf-thymus DNA interacts with complexes via an intercalative mode is studied by electronic absorption titration. Moreover, all these synthesized metal(II) complexes were tested against a set of bacterial and fungal strains reveals that complexes exhibit better activity than free ligand.

Keywords

5-Chloro isatin, 4-Aminoantipyrine, Antimicrobial studies, DNA binding.

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