Physico-Chemical and Biocompatibility of Poly(vinyl alcohol): Polyethylene Glycol/κ-Carragreenan Membrane by Freeze-Gelation Method

Anand V. Nasalapure1,, Raju Krishna Chalannavar2,*, and Deepak R. Kasai3,

1Department of Industrial Chemistry, Mangalore University Mangalgangothri-574199, India

2Department of Applied Botany, Mangalore University Mangalgangothri-574199, India

3Department of Basic Science, School of Engineering and Technology, Jain University, Jakkasandra-562112, India

*Corresponding author: E-mail: drrajkc@gmail.com

Abstract

The aim of this study was to fabricate membrane based on poly(vinyl alcohol) (PVA):polyethylene glycol (PEG)/κ-carragreenan (KC) with different weight ratio (w/v) by freeze gelation method. The prepared membrane was characterized by using SEM, FT-IR, TGA, AFM and XRD techniques. The results revealed that FTIR and SEM showed good molecular interaction among the PVA/PEG with κ-carragreenan. The rate of thermal degradation stabilized with increased κ-carragreenan ratio and also increased the percent of crystallinity. Further water uptake also performed under phosphate buffer saline (PBS) media and results showed increased rate of swelling with increased κ-carragreenan concentration, which enhanced the stability of water uptake. Moreover cell viability performed using MTT method. The highest compatibility showed for lower concentration κ-carragreenan (PVA/PEG/KC10%). Overall results exhibited moderate swelling and degradation, good mechanical properties with strong molecular interaction between PVA/PEG with κ-carragreenan these all characters might have advantage in the field of biomedical applications.

Keywords

Poly(vinyl alcohol), Polyethylene glycol, κ-Carragreenan, Morphology, Biocompatibility.

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