Synthesis, Characterization and Biological Evaluation of Some Novel Regioisomers of Ropivacaine Analogues: An Anaesthetic Drug

S.P.N. Sharavanan1, C.S. Venkatesan2, D. Bhaskara Suresh Raju2 and S. Kabilan1,*

1Department of Chemistry, Faculty of Science, Annamalai University, Annamalai Nagar-608002, India

2Gland Pharma Ltd, Research and Development, D.P. Pally, Hyderabad-500043, India

*Corresponding author: E-mail: profdrskabilanau@gmail.com

Abstract

A series of ropivacaine analogues were synthesized by altering the methyl group substituent in the aromatic ring. The synthesized compounds (2a-f and 3a-f) were characterized by using IR, NMR and HRMS analysis and then compounds 3a-3f were screened in vitro anticancer (MTT assay) activity against breast cancer cell line (MCF-7), antibacterial and antioxidant (DPPH scavenging assay) studies. The biological studies revealed that the compounds 3c and 3f have shown a good inhibitory activity against MCF-7 cell line. Compounds 3e, 3b, 3c and 3f showed moderate antioxidant activity. There was no inhibition observed against both Gram-positive and Gram-negative bacteria.

Keywords

Ropivacaine, Regioisomers, Biological activity.

   View Article PDF File Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.