Determination of Chemical Composition and Antimicrobial Activity of Melaleuca cajuputi Essential Oil from Quang Tri Province, Vietnam

Tran Quoc Toan1,2, Lai Phuong Phuong Thao1, Nguyen Quyet Chien1, Nguyen Thi Hong Van1,2, Ðoan Lan Phuong1,2, Trinh Thu Huong1, Pham Minh Quan1, Cam Thi Inh1, Pham Thi Hong Minh1, Hoang Thi Bich1, Tran Thi Kim Ngan3,4, Than Van Thai3,4, Nguyen Thanh Viet3,4, Long Giang Bach3,4,* and Pham Quoc Long1,2,*

1Institute of Natural Products Chemistry, Vietnam Academy of Science and Technology, Hanoi, Vietnam

2Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Hanoi, Vietnam

3Center of Excellence for Biochemistry and Natural Products, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam

4NTT Hi-Tech Institute, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam

*Corresponding authors: E-mail:;


The essential oil of Melaleuca cajuputi was obtained by hydrodistillation method. This work aims to adopt water as a solvent in a batch process to extract essential oil from Melaleuca cajuputi fresh leaves. The leaves are collected from Quang Tri Province, Vietnam. Analysis of constituents was performed by GC/MS. The maximum yield ranged from 0.6 to 0.7%. Several compounds have been identified in high quantities and meaningful qualitative and quantitative differences have been observed under different conditions. The main components of the M. cajuputi essential oil included eucalyptol (27.512%), γ-terpinene (8.59%), terpinolene (9.047%), β-eudesmene (3.359%), α-selinene (3.889%), α-terpineol (4.108%), 1R-α-pinene (2.158%), caryophyllene (6.48%) and α-caryophyllene (3.522%). This study has confirmed that the essential oil of M. cajuputi essential oil is a promising bactericidal agent on several Gram-positive and Gram-negative bacteria.


Essential oil, Melaleuca cajuputi leaves, Physico-chemical, GC-MS, Chemical composition, Antibacterial activities.

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