Antioxidant and Antidiabetic Activities of Flavonoid Derivative Compounds Isolated from Sclerocarya birrea Leaves

Sithembiso L. Ndwandwe1, Mutendela T. Olivier2 and Sechene S. Gololo1,*

1Department of Biochemistry, School of Science and Technology, Sefako Makgatho Health Sciences University, Ga-Rankuwa (Pretoria), South Africa

2Department of Chemistry, School of Science and Technology, Sefako Makgatho Health Sciences University, Ga-Rankuwa (Pretoria), South Africa

*Corresponding author: E-mail: Stanley.gololo@smu.ac.za

Abstract

Sclerocarya birrea is one of many medicinal plants used in African traditional medicine for treatment of diabetes. Bioassay-guided fractionation of the ethanolic crude extract of the leaves of the plant species led to the isolation of a pure compound (CMP-1). The pure compound showed antioxidant and antidiabetic activities with average IC50 values of 1.04 mg/mL and 46 μg/mL, respectively that were well comparable to the crude extract and known standards compounds, ascorbic acid and quercetin. The spectroscopic profiling of the purified compound revealed a flavonoid derivative structural skeleton. The findings of the study suggested that the flavonoid derivative compounds play a major role towards the medicinal value of Sclerocarya birrea.

Keywords

Sclerocarya birrea, Antioxidant activity, Antidiabetic activity, Flavonoid derivatives.

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