Synthesis, Characterization and Antimicrobial Activities of 1-((5-Bromobenzofuran-2yl)methyl)-4-substituted phenyl-1H-1,2,3-triazoles

P. Sanjeeva1,, B. Subba Rao1,, V. Kamala Prasad2, and P. Venkata Ramana1,*,

1Department of Chemistry, Sri Krishnadevaraya University, Ananthapuramu-515003, India

2Denisco Chemicals Pvt. Ltd., Hyderabad-500055, India

*Corresponding author: E-mail: ramanapv54@gmail.com

Abstract

A synthesis of useful intermediate, 2-(azidomethyl)-5-bromobenzofuran starting from 5-bromobenzofuran-2-carboxylic acid is described. The reaction of 5-bromo-2-(iodomethyl)benzofuran with sodium azide affords 2-(azidomethyl)-5-bromobenzofuran. 5-Bromo-2-(iodomethyl)benzofuran was obtained from a combination of consecutive 5-bromobenzofuran-2-carboxylic acid reactions involving NaBH4 reduction followed by the iodination of the resulting alcohol. The utility of 2-(azidomethyl)-5-bromobenzofuran has been demonstrated for the preparation of a novel series of 1-((5-bromobenzofuran-2-yl-)methyl)-4-substituted phenyl-1H-1,2,3-triazoles in excellent yields. The newly synthesized compounds have been characterized and evaluated for antimicrobial activities against Gram-negative and Gram-positive bacterial strains.

Keywords

2-(Azidomethyl)-5-bromobenzofuran, Substituted benzofuran, Triazole, Antimicrobial activity, Antibacterial activity.

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