Synthesis and Characterization of 3-Substituted Indole Derivatives as Novel Mannich Bases

E. Erdag

Department of Pharmaceutical Chemistry, Near East University, Faculty of Pharmacy, Nicosia, Turkish Republic of Northern Cyprus

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In this study, ten 3-substituted indole derivatives at the 3rd position of indole nucleus were synthesized via Mannich reaction with microwave assisted synthesis and the conventional reflux heating method. Microwave assisted synthesis is more preferrable than reflux method since the microwave irradiation lead to a higher product yields with better purity and improved energy efficiency with shortened reaction time. The structures of 3-substituted indole derivatives were characterized by FT-IR, elemental analysis, 1H NMR and 13C NMR spectroscopy.


Mannich reaction, Indole, 4-Substituted piperazines, Microwave-assisted synthesis.

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