An Efficient Suitable Synthesis for Pyrazole, Pyrimidine Derivatives and Biological Evaluation

S. Syed Shafi1,*,, P. Subashini1,, S. Gajalakshmi1, and V. Vijaya Kumar2,

1Department of Chemistry, Thiruvalluvar University, Serkkadu, Vellore-632115, India

2Department of Chemistry, Voorhees College, Vellore-632001, India

*Corresponding author: E-mail: suban_shafi@yahoo.com

Abstract

Novel quinazoline derivatives were synthesized by reacting isatoic anhydride and 4-amino acetanilide to synthesize N-(4-(2,4-dioxo-1,2-dihydroquinazolin-3(4H)-yl)phenyl)acetamide which in turn reacted with substituted aromatic aldehydes to synthesize novel chalcones. The chalcones were allowed to react with hydrazine hydrochloride and guanidine to form pyrazoline and pyrimidine derivatives, respectively. The newly synthesized compounds were characterized by IR, NMR (1H, 13C), mass and elemental analysis. All the newly synthesized derivatives were screened for in vitro antimicrobial and antioxidant activities to evaluate their biological potency.

Keywords

Quinazoline, Chalcones, Pyrazoline, Pyrimidine, Antimicrobial, Antioxidant.

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