Bioactive Phytochemical Compounds of Physalis minima L. and its Anticholinesterase and Antioxidant Activities

V. Prabhu1, K. Arunkumar2, B. Monika1, V. Latha3 and G. Sibi4,*,

1P.G. Department of Chemistry, Nallamuthu Gounder Mahalingam College, Pollachi-642001, India

2Faculty of Chemistry, Hindusthan Polytechnic College, Coimbatore-641032, India

3Department of Chemistry, Indian Academy Degree College (Autonomous), Bengaluru-560043, India

4Department of Biotechnology, Indian Academy Degree College (Autonomous), Bengaluru-560043, India

*Corresponding author: E-mail: gsibii@gmail.com

Abstract

Physalis minima Linn. was investigated for its antioxidant and acetylcholine esterase inhibition activities. The methanolic extract of the whole plant was evaluated for radical scavenging and in vitro hydrolysis of acetylthiocholine iodide. Inhibitory concentration (IC50) of the extract exhibited IC50 values of 78.6, 46.2, 76.7 and 296 μg/mL under 2,2-diphenyl-1-picrylhydrazyl (DPPH), ABTS (2,2′-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid)), hydroxyl radical scavenging and acetylcholine esterase inhibition assays. GC-MS analysis revealed the presence of 11 compounds of which most of the compounds were reported with biological activities. The study suggests further investigations of P. minima for isolation, purification and characterization of valuable bioactive compounds related to their radical scavenging activity and for the treatment of neurodegenerative disease.

Keywords

Physalis minima, Antioxidant activity, Acetylcholine esterase.

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